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By recording activity of specific neurons in the brain, researchers aim to pick up signals of intended speech.
Knowable Magazine
In Alexandre Dumas’s classic novel The Count of Monte Cristo, a character named Monsieur Noirtier de Villefort suffers a terrible stroke that leaves him paralyzed. Though he remains awake and aware, he is no longer able to move or speak, relying on his granddaughter Valentine to recite the alphabet and flip through a dictionary to find the letters and words he requires. With this rudimentary form of communication, the determined old man manages to save Valentine from being poisoned by her stepmother and thwart his son’s attempts to marry her off against her will.
Dumas’s portrayal of this catastrophic condition—where, as he puts it, “the soul is trapped in a body that no longer obeys its commands”—is one of the earliest descriptions of locked-in syndrome. This form of profound paralysis occurs when the brain stem is damaged, usually because of a stroke but also as the result of tumors, traumatic brain injury, snakebite, substance abuse, infection or neurodegenerative diseases like amyotrophic lateral sclerosis (ALS).
In The Count of Monte-Cristo, Monsieur Noirtier de Villefort cannot move or speak but communicates with his granddaughter through words and letters in a book./https://tf-cmsv2-smithsonianmag-media.s3.amazonaws.com/filer_public/a2/98/a29878ba-88e3-43fe-ad4d-1786733a8c06/i-noirtier-de-villeforte.jpg)
The condition is thought to be rare, though just how rare is hard to say. Many locked-in patients can communicate through purposeful eye movements and blinking, but others can become completely immobile, losing their ability even to move their eyeballs or eyelids, rendering the command “blink twice if you understand me” moot. As a result, patients can spend an average of 79 days imprisoned in a motionless body, conscious but unable to communicate, before they are properly diagnosed.
The advent of brain-machine interfaces